HIV PROTEASE INHIBITORS DISRUPT LIPID METABOLISM BY ACTIVATING ENDOPLASMIC RETICULUM STRESS AND INHIBITING AUTOPHAGY ACTIVITY IN ADIPOCYTES.

HIV protease inhibitors disrupt lipid metabolism by activating endoplasmic reticulum stress and inhibiting autophagy activity in adipocytes.

BackgroundHIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART), the most effective treatment for HIV infection currently available.However, HIV PIs have now been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular disease and metabolic syndrome.Our previous studies ha

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Evaluation of Commercial Reverse Osmosis and Nanofiltration Membranes for the Removal of Heavy Metals from Surface Water in the Democratic Republic of Congo

This study evaluates the performance of commercial reverse osmosis (RO) and nanofiltration (NF) membranes for the removal of metal ions from synthetic water and surface water carried from the north-west of Lake Tanganyika in the city of Uvira, in the east of the Democratic Republic of Congo.Metal Electric Pump Seal ion analyses were performed by th

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Perceptions and attitudes of black men in a rural district of South Africa towards depression and its treatment

Background: Depression is a major contributor to the overall global burden of disease, impacting social life, family life Handriers and occupational functioning if left untreated.Despite its high prevalence and morbidity, the evidence suggests that men are hesitant to seek help, with a large percentage remaining undiagnosed.This study aimed to dete

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Bis(η2-ethylene)(η5-indenyl)iridium(I)

The asymmetric unit of the title compound, [Ir(C9H7)(C2H4)2], consists of two independent molecules.The bonding between iridium and the five-membered ring of the indenyl ligand shows the usual asymmetry associated with the typical ring slippage responsible for the enhanced activity of indenyl metal compounds when compared with the analogous cyclope

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